Article
Differential carbonylation of cytoskeletal proteins in blood group O erythrocytes: potential role in protection against severe malaria.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Dec 2012
Méndez Darío, Hernáez María L, Kamali Ali N, Diez Amalia, Puyet Antonio, Bautista José M
Abstract excerpt
The molecular basis for the prevalence of blood group O in regions where malaria is endemic remains unclear. In some genetic backgrounds oxidative modifications have been linked to a reduced susceptibility to severe malaria disease. Through redox proteomics, we detected differences in carbonylated membrane proteins among the different blood groups, both in Plasmodium-infected and uninfected erythrocytes (RBC)....
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