Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Unusual clinical severity of complement membrane cofactor protein-associated hemolytic-uremic syndrome and uniparental isodisomy.

American journal of kidney diseases : the official journal of the National Kidney Foundation - 1 Feb 2007

Fremeaux-Bacchi Veronique, Sanlaville Damien, Menouer Soraya, Blouin Jacques, Dragon-Durey Marie-Agnès, Fischbach Michel, Vekemans Michel, Fridman Wolf Herman

Abstract excerpt

Atypical hemolytic-uremic syndrome (aHUS; OMIM 235400) is genetically and clinically heterogeneous. Mutations in membrane cofactor protein (MCP; CD46), a widely expressed complement regulator, predispose to recurrent forms of the disease. Patients carrying MCP mutations have a favorable clinical outcome in comparison to those with factor H (CFH) or factor I (IF) mutations, which lead in most cases to end-stage...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Child
Share to Cohort Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to CFH gene

Share to Hemolytic-Uremic Syndrome

Share to Membrane Cofactor Protein

Share to Mutation

Share to Severity of Illness Index

Share to Uniparental Disomy

Source

Identifiers

PMID: 17261436
DOI: 10.1053/j.ajkd.2006.10.022

Genes

CFH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Unusual clinical severity of complement membrane cofactor protein-associated hemolytic-uremic syndrome and uniparental isodisomy.PMID 17261436Read ↗

Implications of the initial mutations in membrane cofactor protein (MCP; CD46) leading to atypical hemolytic uremic syndrome.Semantic proximity Read ↗

Inherited deficiency of membrane cofactor protein expression and varying manifestations of recurrent atypical hemolytic uremic syndrome in a sibling pair.Semantic proximity Read ↗

Genetic and functional analyses of membrane cofactor protein (CD46) mutations in atypical hemolytic uremic syndrome.Semantic proximity Read ↗

Insights into hemolytic uremic syndrome: segregation of three independent predisposition factors in a large, multiple affected pedigree.Semantic proximity Read ↗

Atypical haemolytic uraemic syndrome.Semantic proximity Read ↗

Mutations in complement factor I predispose to development of atypical hemolytic uremic syndrome.Semantic proximity Read ↗

Rapid recovery of membrane cofactor protein (MCP; CD46) associated atypical haemolytic uraemic syndrome with plasma exchange.Semantic proximity Read ↗

Genotype/phenotype correlations in complement factor H deficiency arising from uniparental isodisomy.Semantic proximity Read ↗

Predisposition to atypical hemolytic uremic syndrome involves the concurrence of different susceptibility alleles in the regulators of complement activation gene cluster in 1q32.Semantic proximity Read ↗

Membrane cofactor protein mutations in atypical hemolytic uremic syndrome (aHUS), fatal Stx-HUS, C3 glomerulonephritis, and the HELLP syndrome.Semantic proximity Read ↗

Differential impact of complement mutations on clinical characteristics in atypical hemolytic uremic syndrome.Semantic proximity Read ↗

Complement dysfunction in hemolytic uremic syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.