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Article

Mutations in complement factor I predispose to development of atypical hemolytic uremic syndrome.

Journal of the American Society of Nephrology : JASN - 1 Jul 2005

Kavanagh David, Kemp Elizabeth J, Mayland Elizabeth, Winney Robin J, Duffield Jeremy S, Warwick Graham, Richards Anna, Ward Roy, Goodship Judith A, Goodship Timothy H J

Abstract excerpt

Mutations in the plasma complement regulator factor H (CFH) and the transmembrane complement regulator membrane co-factor protein (MCP) have been shown to predispose to atypical hemolytic uremic syndrome (HUS). Both of these proteins act as co-factors for complement factor I (IF). IF is a highly...

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Source

Identifiers

PMID: 15917334
DOI: 10.1681/ASN.2005010103

Genes

CFH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15917334-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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