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Article

Insights into hemolytic uremic syndrome: segregation of three independent predisposition factors in a large, multiple affected pedigree.

Molecular immunology - 1 Apr 2006

Esparza-Gordillo Jorge, Jorge Elena Goicoechea de, Garrido Cynthia Abarrategui, Carreras Luis, López-Trascasa Margarita, Sánchez-Corral Pilar, de Córdoba Santiago Rodríguez

Abstract excerpt

Mutations in the complement regulators factor H, membrane cofactor protein (MCP), and factor I are associated with atypical hemolytic uremic syndrome (aHUS, MIM 235400), suggesting that the disease develops as a consequence of the inefficient protection of the renal endothelium from damage by the complement system. Incomplete penetrance of the disease in individuals carrying these mutations is, however,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16386793
DOI: 10.1016/j.molimm.2005.11.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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