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Article

Genetic and functional analyses of membrane cofactor protein (CD46) mutations in atypical hemolytic uremic syndrome.

Journal of the American Society of Nephrology : JASN - 1 Jul 2006

Fremeaux-Bacchi Véronique, Moulton Elizabeth A, Kavanagh David, Dragon-Durey Marie-Agnès, Blouin Jacques, Caudy Amy, Arzouk Nadia, Cleper Roxanna, Francois Maud, Guest Genevieve, Pourrat Jacques, Seligman Roland, Fridman Wolf Herman, Loirat Chantal, Atkinson John P

Abstract excerpt

Hemolytic uremic syndrome (HUS) is characterized by the triad of thrombocytopenia, microangiopathic hemolytic anemia, and acute renal failure. The non-Shiga toxin-associated HUS (atypical HUS [aHUS]) has been shown to be a disease of complement dysregulation. Mutations in the plasma complement regulators factor H and factor I and the widely expressed membrane cofactor protein (MCP; CD46) have been described...

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Identifiers

PMID: 16762990
DOI: 10.1681/ASN.2005101051

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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