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Article

Noncanonical function of DGCR8 controls mESC exit from pluripotency.

The Journal of cell biology - 1 Feb 2017

Cirera-Salinas Daniel, Yu Jian, Bodak Maxime, Ngondo Richard P, Herbert Kristina M, Ciaudo Constance

Abstract excerpt

Mouse embryonic stem cells (mESCs) deficient for DGCR8, a key component of the microprocessor complex, present strong differentiation defects. However, the exact reasons impairing their commitment remain elusive. The analysis of newly generated mutant mESCs revealed that DGCR8 is essential for the exit from the pluripotency state. To dissociate canonical versus noncanonical functions of DGCR8, we complemented the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28100686
DOI: 10.1083/jcb.201606073
PMCID: PMC5294780

Genes

DGCR8

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