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Article

Development of lung cancer before the age of 50: the role of xenobiotic metabolizing genes.

Carcinogenesis - 1 Jun 2007

Gemignani Federica, Landi Stefano, Szeszenia-Dabrowska Neonilia, Zaridze David, Lissowska Jolanta, Rudnai Peter, Fabianova Eleonora, Mates Dana, Foretova Lenka, Janout Vladimir, Bencko Vladimir, Gaborieau Valérie, Gioia-Patricola Lydie, Bellini Ilaria, Barale Roberto, Canzian Federico, Hall Janet, Boffetta Paolo, Hung Rayjean J, Brennan Paul

Abstract excerpt

The role of genes coding for xenobiotic metabolizing enzymes (XMEs) and the risk of lung cancer is unclear. Under the assumption that these genes may be more important among people having a diagnosis of lung cancer at younger ages, we have investigated the role of single-nucleotide polymorphisms (SNPs) within phase I and phase II XME genes, and also genes involved in the metabolism of nucleic acids in a series of...

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Source

Identifiers

PMID: 17259654
DOI: 10.1093/carcin/bgm021

Genes

NAT1
NAT2
EPHX1
GSTA2
GSTM3
MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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