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Article

A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of non-small cell lung cancer in smokers.

Carcinogenesis - 1 Jun 2008

Zienolddiny Shanbeh, Campa Daniele, Lind Helge, Ryberg David, Skaug Vidar, Stangeland Lodve B, Canzian Federico, Haugen Aage

Abstract excerpt

Lung cancer is a leading cause of cancer mortality worldwide with smoking and occupational exposure to carcinogenic compounds as the major risk factors. Susceptibility to lung cancer is affected by existence of polymorphic genes controlling the levels of metabolic activation and detoxification of carcinogens. We have investigated 105 single nucleotide polymorphisms (SNPs) in 31 genes from the phase I and phase II...

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Source

Identifiers

PMID: 18258609
DOI: 10.1093/carcin/bgn020

Genes

COMT
EPHX1
GSTP1
NAT1
SOD2
ALDH2
GSTM3
MPO
NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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