Article
Identification of amino acid residues of Salmonella SlyA that are critical for transcriptional regulation.
Microbiology (Reading, England) - 1 Feb 2007
Okada Nobuhiko, Oi Yorie, Takeda-Shitaka Mayuko, Kanou Kazuhiko, Umeyama Hideaki, Haneda Takeshi, Miki Tsuyoshi, Hosoya Sachiko, Danbara Hirofumi
Abstract excerpt
The type III secretion system encoded by Salmonella pathogenicity island 2 (SPI-2) is essential for the intracellular survival and replication of Salmonella enterica. The expression of SPI-2 genes is dependent on a two-component regulatory system, SsrA (SpiR)/SsrB, encoded in the SPI-2 region. This paper shows that SlyA regulates transcription of the sensor kinase SsrA by binding to the ssrA promoter, indicating...
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