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Article

Transcriptional activation of Salmonella typhimurium invasion genes by a member of the phosphorylated response-regulator superfamily.

Molecular microbiology - 1 Nov 1996

Johnston C, Pegues D A, Hueck C J, Lee A, Miller S I

Abstract excerpt

The Salmonella typhimurium PhoP-repressed locus prgHIJK encodes components of a sec-independent type III secretion apparatus. This apparatus is composed of at least 17 proteins encoded on a 40 kb pathogenicity Island located at centisome 63 on the S. typhimurium chromosome. The secretion apparatus and some of its targets, SapB, SapC and SspD, are necessary for epithelial cell invasion. The transcription of many...

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PMID: 8951818
DOI: 10.1046/j.1365-2958.1996.d01-1719.x

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