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Article

Hypoxia inducible factor-1α as a cancer drug target

1 May 2004

Abstract excerpt

The hypoxia inducible factor 1 (HIF-1) is a heterodimeric transcription factor that is an important regulator of the growing tumor's response to hypoxia. HIF-1 activity in tumors depends on the availability of the HIF-1alpha subunit, the levels of which increase under hypoxic conditions and through the activation of oncogenes and/or inactivation of tumor suppressor genes. HIF-1 activates genes that allow the...

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PMID: 15141023
DOI: 10.1158/1535-7163.647.3.5

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