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Article

Growth factor receptor interplay and resistance in cancer

1 Dec 2006

Abstract excerpt

Aberrant signalling through the epidermal growth factor receptor (EGFR) plays a major role in the progression and maintenance of the malignant phenotype and the receptor is therefore a rational anti-cancer target. A variety of approaches have been developed to specifically target the EGFR which include monoclonal antibodies and small molecule tyrosine kinase inhibitors, such as gefitinib (Iressa). However, the...

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PMID: 17259558
DOI: 10.1677/erc.1.01275

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