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Article

Molecular biology of epidermal growth factor receptor inhibition for cancer therapy

17 May 2006

Abstract excerpt

Understanding the role of the epidermal growth factor receptor (EGFR) in cellular signalling processes underlying malignancy has enabled the development of rationally designed EGFR-targeted therapeutics. Strategies have been devised to interfere with the EGFR signalling at three different levels: at the extracellular level, competing with ligand binding; at the intracellular level, inhibiting the activation of...

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PMID: 16706607
DOI: 10.1517/14712598.6.6.605

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