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Article

Insulin-like growth factor-1 receptor (IGF-1R) as a biomarker for resistance to the tyrosine kinase inhibitor gefitinib in non-small cell lung cancer.

Cellular oncology (Dordrecht, Netherlands) - 1 Jul 2013

Peled Nir, Wynes Murry W, Ikeda Norihiko, Ohira Tatsuo, Yoshida Koichi, Qian Jin, Ilouze Maya, Brenner Ronen, Kato Yasufumi, Mascaux Celine, Hirsch Fred R

Abstract excerpt

BACKGROUND: The insulin-like growth factor-1 receptor (IGF-1R) pathway is known to play a role in the acquisition of resistance to epidermal growth factor receptor (EGFR)-specific tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer (NSCLC). However, its exact role in TKI resistance ha...

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Source

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Identifiers

PMID: 23619944
DOI: 10.1007/s13402-013-0133-9
PMCID: PMC4186686

Genes

EGFR
IGF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23619944-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Insulin-like growth factor-1 receptor (IGF-1R) as a biomarker for resistance to the tyrosine kinase inhibitor gefitinib in non-small cell lung cancer.PMID 23619944Read ↗

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