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Article

Bone Morphogenetic Proteins Induce Germ Cell Differentiation from Human Embryonic Stem Cells

1 Dec 2006

Abstract excerpt

The growth factors bone morphogenetic protein-4 (BMP4), BMP7, and BMP8b are required for specification of primordial germ cells (PGCs) in mice. Disruption of the genes that encode these factors leads to a severe reduction in number, or the complete absence, of PGCs. In addition, several studies have demonstrated that human BMP4 can promote PGC differentiation from mouse embryonic stem (ES) cells and in organ...

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Identifiers

PMID: 17253946
DOI: 10.1089/scd.2006.15.831

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Bone Morphogenetic Proteins Induce Germ Cell Differentiation from Human Embryonic Stem CellsPMID 17253946Read ↗

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Induction of primordial germ cells from mouse induced pluripotent stem cells derived from adult hepatocytesSemantic proximity Read ↗

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Derivation of male germ cells from induced pluripotent stem cells <i>in vitro</i> and in reconstituted seminiferous tubulesSemantic proximity Read ↗

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