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BMP4 can generate primordial germ cells from bone‐marrow‐derived pluripotent stem cells

25 Sept 2012

Abstract excerpt

Evidence of germ cell derivation from embryonic and somatic stem cells provides an in vitro model for the study of germ cell development, associated epigenetic modification and mammalian gametogenesis. More importantly, in vitro derived gametes also represent a potential strategy for treating infertility. In mammals, male and female gametes, oocyte and sperm, are derived from a specific cell population, PGCs...

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PMID: 22988836
DOI: 10.1042/cbi20110651

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