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BMP4 promotes SSEA‐1+ hUC ‐MSC differentiation into male germ‐like cells in vitro

13 Jun 2014

Abstract excerpt

OBJECTIVES: Recent studies have demonstrated that primordial germ cells (PGC) can be differentiated from human umbilical cord mesenchymal stem cells (hUC-MSCs), and embryonic stem cells (ESCs) in vitro. Nevertheless, efficiencies were low and unstable. Here, whether hUC-MSCs can be induced to differentiate into germ-like cells with the aid of bone morphogenetic protein (BMP4) was investigated. MATERIALS AND...

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PMID: 24923741
DOI: 10.1111/cpr.12115

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