Article
Streptomycin resistance in mycobacteria.
Antimicrobial agents and chemotherapy - 1 Feb 1994
Honoré N, Cole S T
Abstract excerpt
Streptomycin, the first antibiotic used in tuberculosis control programs, perturbs protein synthesis at the ribosome level. It is shown here that streptomycin resistance in some clinical isolates of Mycobacterium tuberculosis is associated either with missense mutations in the rpsL gene, which en...
Topics
- Amino Acid Sequence
- Bacterial Proteins
- Base Sequence
- DNA Primers
- DNA, Bacterial
- DNA, Single-Stranded
- Drug Resistance, Microbial
- Genes, Bacterial
- Molecular Sequence Data
- Mutation
- Mycobacterium
- Mycobacterium tuberculosis
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Ribosomal Proteins
- Streptomycin