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Article

Streptomycin resistance in mycobacteria.

Antimicrobial agents and chemotherapy - 1 Feb 1994

Honoré N, Cole S T

Abstract excerpt

Streptomycin, the first antibiotic used in tuberculosis control programs, perturbs protein synthesis at the ribosome level. It is shown here that streptomycin resistance in some clinical isolates of Mycobacterium tuberculosis is associated either with missense mutations in the rpsL gene, which encodes ribosomal protein S12, or with base substitutions at position 904 in the 16S rRNA. The primary structure of the...

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Identifiers

PMID: 8192450
DOI: 10.1128/AAC.38.2.238
PMCID: PMC284433

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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