Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Delayed wound closure and phenotypic changes in corneal epithelium of the spontaneously diabetic Goto-Kakizaki rat.

Investigative ophthalmology & visual science - 1 Feb 2007

Wakuta Makiko, Morishige Naoyuki, Chikama Tai-Ichiro, Seki Keisuke, Nagano Takashi, Nishida Teruo

Abstract excerpt

PURPOSE: To characterize wound closure and phenotypic changes in the corneal epithelium of the Goto-Kakizaki (GK) rat, a spontaneous model of type 2 diabetes. METHODS: Corneal wound healing was monitored by fluorescein staining after epithelial debridement. Tear secretion was measured with the Schirmer test, and corneal sensation was evaluated with an esthesiometer in 13- to 15-week-old GK and Wistar (control)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Connexin 43
Share to Corneal Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelium, Corneal

Share to Fluorescent Antibody Technique, Indirect

Share to Keratin-14

Share to Ki-67 Antigen

Share to Microscopy, Immunoelectron

Share to Rats, Mutant Strains

Source

Identifiers

PMID: 17251454
DOI: 10.1167/iovs.05-1168

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Delayed wound closure and phenotypic changes in corneal epithelium of the spontaneously diabetic Goto-Kakizaki rat.PMID 17251454Read ↗

Effect of Tear Derived Exosomes on Corneal Epithelial Cells During Diabetic KeraropathySemantic proximity Read ↗

Genome-Wide Transcriptional Analysis of Differentially Expressed Genes in Diabetic, Healing Corneal Epithelial Cells: Hyperglycemia-Suppressed TGFβ3 Expression Contributes to the Delay of Epithelial Wound Healing in Diabetic CorneasSemantic proximity Read ↗

Non-invasive electrical stimulation restores corneal nerve density and function in diabetic neuropathy via KCNN-dependent mechanismSemantic proximity Read ↗

DBA/2J mice are susceptible to diabetic nephropathy and diabetic exacerbation of IOP elevation.Semantic proximity Read ↗

Phenotypic Investigation of Regenerated Epithelial Cells After Gonococcal Corneal Perforation: A Clinical, Histological, and Immunohistochemical Study.Semantic proximity Read ↗

Evidence for a phenotypic switch in corneal afferents after lacrimal gland excision.Semantic proximity Read ↗

A transient receptor potential vanilloid 1-dependent corneal-trigeminal neuroinflammatory circuit promotes corneal neuropathySemantic proximity Read ↗

Changes in corneal basal epithelial phenotypes in an altered basement membrane.Semantic proximity Read ↗

A transient receptor potential vanilloid 1-dependent corneal-trigeminal neuroinflammatory circuit promotes corneal neuropathySemantic proximity Read ↗

Loss of NHE8 expression impairs ocular surface function in mice.Semantic proximity Read ↗

Effects of the loss of conjunctival Muc16 on corneal epithelium and stroma in mice.Semantic proximity Read ↗

AG1295 Attenuates High-Glucose-Induced Proliferation, Migration, Phenotype Transition, and Interleukin-6 Expression in Human Corneal Stromal Fibroblasts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.