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Article

AG1295 Attenuates High-Glucose-Induced Proliferation, Migration, Phenotype Transition, and Interleukin-6 Expression in Human Corneal Stromal Fibroblasts.

Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics - 1 Sept 2026

Zheng Yuwei, Jiang Huimin, Wang Jing, Zhang Qing, Wan Qianqian, Wang Yan

Abstract excerpt

PURPOSE: Up to 46%-64% of individuals with diabetes exhibit corneal abnormalities, including epithelial dysfunction and reduced sensitivity, which may gradually impair corneal transparency. Corneal fibroblasts regulate scar formation and play a critical role in maintaining corneal transparency. This study investigated the effects of high-glucose levels on fibroblasts and elucidated the underlying mechanisms....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41852028
DOI: 10.1177/10807683261433333

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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