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Article

The induction levels of heat shock protein 70 differentiate the vulnerabilities to mutant huntingtin among neuronal subtypes.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 24 Jan 2007

Tagawa Kazuhiko, Marubuchi Shigeki, Qi Mei-Ling, Enokido Yasushi, Tamura Takuya, Inagaki Reina, Murata Miho, Kanazawa Ichiro, Wanker Erich E, Okazawa Hitoshi

Abstract excerpt

The reason why vulnerabilities to mutant polyglutamine (polyQ) proteins are different among neuronal subtypes is mostly unknown. In this study, we compared the gene expression profiles of three types of primary neurons expressing huntingtin (htt) or ataxin-1. We found that heat shock protein 70 (hsp70), a well known chaperone molecule protecting neurons in the polyQ pathology, was dramatically upregulated only by...

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Identifiers

PMID: 17251428
DOI: 10.1523/JNEUROSCI.4522-06.2007
PMCID: PMC6672912

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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