Article
Molecular determinants of antiviral potency of paramyxovirus entry inhibitors.
Journal of virology - 1 Oct 2007
Porotto M, Carta P, Deng Y, Kellogg G E, Whitt M, Lu M, Mungall B A, Moscona A
Abstract excerpt
Hendra virus (HeV) and Nipah virus (NiV) constitute the Henipavirus genus of paramyxoviruses, both fatal in humans and with the potential for subversion as agents of bioterrorism. Binding of the HeV/NiV attachment protein (G) to its receptor triggers a series of conformational changes in the fusion protein (F), ultimately leading to formation of a postfusion six-helix bundle (6HB) structure and fusion of the...
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