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Article

The C-terminal region of G72 increases D-amino acid oxidase activity.

International journal of molecular sciences - 20 Dec 2013

Chang Sunny Li-Yun, Hsieh Chia-Hung, Chen Yen-Ju, Wang Chien-Ming, Shih Chung-Shiuan, Huang Pei-Wen, Mir Asif, Lane Hsien-Yuan, Tsai Guochuan E, Chang Hao-Teng

Abstract excerpt

The schizophrenia-related protein G72 plays a unique role in the regulation of D-amino acid oxidase (DAO) in great apes. Several psychiatric diseases, including schizophrenia and bipolar disorder, are linked to overexpression of DAO and G72. Whether G72 plays a positive or negative regulatory role in DAO activity, however, has been controversial. Exploring the molecular basis of the relationship between G72 and...

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Identifiers

PMID: 24362575
DOI: 10.3390/ijms15010029
PMCID: PMC3907796

Genes

DAO

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