Article
Association between the DAOA/G72 gene and bipolar disorder and meta-analyses in bipolar disorder and schizophrenia.
Bipolar disorders - 1 Mar 2011
Müller Daniel J, Zai Clement C, Shinkai Takahiro, Strauss John, Kennedy James L
Abstract excerpt
OBJECTIVE: The D-amino acid oxidase activator (DAOA, or G72) is involved in the oxidation of D-serine, an endogenous modulator of N-methyl-D-aspartate receptors and thus represents an important candidate in psychotic disorders. Several studies reported the DAOA/G72 gene to be associated with schizophrenia (SZ) and bipolar disorder (BD); however, the associated polymorphisms varied between SZ and BD. This study...
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