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Article

Expression of Indian Hedgehog, BMP-4 and Noggin in craniosynostosis induced by fetal constraint.

Annals of plastic surgery - 1 Feb 2007

Jacob Shushan, Wu Changshan, Freeman Theresa A, Koyama Eiki, Kirschner Richard E

Abstract excerpt

Indian Hedgehog (Ihh), bone morphogenetic protein (BMP), and its antagonist Noggin play an important regulatory role in bone formation. We used an animal model to study the role of these molecules in craniosynostosis induced by fetal constraint. C57Bl/6 mice underwent cervical cerclage on the 18th day of gestation, and their pups were harvested 48 and 72 hours beyond the normal gestational period. Constrained and...

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Identifiers

PMID: 17245153
DOI: 10.1097/01.sap.0000232833.41739.a5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Expression of Indian Hedgehog, BMP-4 and Noggin in craniosynostosis induced by fetal constraint.PMID 17245153Read ↗

Indian hedgehog in craniofacial neural crest cells links to skeletal malocclusion by regulating associated cartilage formation and gene expression.Semantic proximity Read ↗

Ihh controls cartilage development by antagonizing Gli3, but requires additional effectors to regulate osteoblast and vascular development.Semantic proximity Read ↗

Inactivation of Ihh in Sp7-Expressing Cells Inhibits Osteoblast Proliferation, Differentiation, and Bone Formation, Resulting in a Dwarfism Phenotype with Severe Skeletal Dysplasia in Mice.Semantic proximity Read ↗

The transcription factor Foxc1 is necessary for Ihh–Gli2-regulated endochondral ossificationSemantic proximity Read ↗

Single-cell analysis identifies a key role for Hhip in murine coronal suture development.Semantic proximity Read ↗

Ectopic Hedgehog Signaling Causes Cleft Palate and Defective Osteogenesis.Semantic proximity Read ↗

Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation.Semantic proximity Read ↗

Indian hedgehog synchronizes skeletal angiogenesis and perichondrial maturation with cartilage development.Semantic proximity Read ↗

Core binding factor beta (Cbfβ) controls the balance of chondrocyte proliferation and differentiation by upregulating Indian hedgehog (Ihh) expression and inhibiting parathyroid hormone-related protein receptor (PPR) expression in postnatal cartilage and bone formation.Semantic proximity Read ↗

Molecular Analysis of Gli3, Ihh, Rab23, and Jag1 in a Rabbit Model of Craniosynostosis: Likely Exclusion as the Loci of Origin.Semantic proximity Read ↗

BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiationSemantic proximity Read ↗

Conditional Deletion of Indian Hedgehog in Limb Mesenchyme Results in Complete Loss of Growth Plate Formation but Allows Mature Osteoblast Differentiation.Semantic proximity Read ↗

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