Article
Single-cell analysis identifies a key role for Hhip in murine coronal suture development.
Nature communications - 8 Dec 2021
Holmes Greg, Gonzalez-Reiche Ana S, Saturne Madrikha, Motch Perrine Susan M, Zhou Xianxiao, Borges Ana C, Shewale Bhavana, Richtsmeier Joan T, Zhang Bin, van Bakel Harm, Jabs Ethylin Wang
Abstract excerpt
Craniofacial development depends on formation and maintenance of sutures between bones of the skull. In sutures, growth occurs at osteogenic fronts along the edge of each bone, and suture mesenchyme separates adjacent bones. Here, we perform single-cell RNA-seq analysis of the embryonic, wild type murine coronal suture to define its population structure. Seven populations at E16.5 and nine at E18.5 comprise the...
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