Article
Transcripts targeted by the microRNA-16 family cooperatively regulate cell cycle progression.
Molecular and cellular biology - 1 Mar 2007
Linsley Peter S, Schelter Janell, Burchard Julja, Kibukawa Miho, Martin Melissa M, Bartz Steven R, Johnson Jason M, Cummins Jordan M, Raymond Christopher K, Dai Hongyue, Chau Nelson, Cleary Michele, Jackson Aimee L, Carleton Michael, Lim Lee
Abstract excerpt
microRNAs (miRNAs) are abundant, approximately 21-nucleotide, noncoding regulatory RNAs. Each miRNA may regulate hundreds of mRNA targets, but the identities of these targets and the processes they regulate are poorly understood. Here we have explored the use of microarray profiling and functional screening to identify targets and biological processes triggered by the transfection of human cells with miRNAs. We...
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