Article
The novel dominant mutation Dspd leads to a severe spermiogenesis defect in mice.
Biology of reproduction - 1 Apr 2004
Kai Masayuki, Irie Masahito, Okutsu Tomohisa, Inoue Kimiko, Ogonuki Narumi, Miki Hiromi, Yokoyama Minesuke, Migishima Rika, Muguruma Kaori, Fujimura Hisako, Kohda Takashi, Ogura Atsuo, Kaneko-Ishino Tomoko, Ishino Fumitoshi
Abstract excerpt
Spermiogenesis is a complex process that is regulated by a plethora of genes and interactions between germ and somatic cells. Here we report a novel mutant mouse strain that carries a transgene insertional/translocational mutation and exhibits dominant male sterility. We named the mutation dominant spermiogenesis defect (Dspd). In the testes of Dspd mutant mice, spermatids detached from the seminiferous...
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