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Article

FoxO4 regulates tumor necrosis factor alpha-directed smooth muscle cell migration by activating matrix metalloproteinase 9 gene transcription.

Molecular and cellular biology - 1 Apr 2007

Li Hao, Liang Jianping, Castrillon Diego H, DePinho Ronald A, Olson Eric N, Liu Zhi-Ping

Abstract excerpt

Phenotypic modulation of vascular smooth muscle cells (SMCs) in the blood vessel wall from a differentiated to a proliferative state during vascular injury and inflammation plays an important role in restenosis and atherosclerosis. Matrix metalloproteinase 9 (MMP9) is a member of the MMP family of proteases, which participate in extracellular matrix degradation and turnover. MMP9 is upregulated and required for...

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Source

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Identifiers

PMID: 17242183
DOI: 10.1128/MCB.01748-06
PMCID: PMC1899894

Genes

MMP9
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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