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FOXO1 deletion in keratinocytes improves diabetic wound healing through MMP9 regulation

30 Aug 2017

Abstract excerpt

Abstract Keratinocyte migration is a key aspect of re-epithelialization during wound healing. Matrix metalloproteinase 9 (MMP9) contributes to this process and deficiencies in the MMP9 lead to impaired healing. Inappropriate expression of MMP9 also contributes to impaired re-epithelialization. Previously we demonstrated that FOXO1 was activated in wound healing but to higher levels in diabetic wounds. To address...

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PMID: 28874756
DOI: 10.1038/s41598-017-10999-3

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