Article

Systemic Proteome Phenotypes Reveal Defective Metabolic Flexibility in Mecp2 Mutants

2023-04-04

Abstract excerpt

Genes mutated in monogenic neurodevelopmental disorders are broadly expressed. This observation supports the concept that monogenic neurodevelopmental disorders are systemic diseases that profoundly impact neurodevelopment. We tested the systemic disease model focusing on Rett syndrome, which is caused by mutations in MECP2 . Transcriptomes and proteomes of organs and brain regions from Mecp2 -null mice as well...

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Literature Corpus work: a3030f04-3c51-5b3f-8ba5-507f1152389c
DOI: 10.1101/2023.04.03.535431

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