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Article

Infrequent hypermethylation of <i>CEBPA</i> promotor in acute myeloid leukaemia

1 Dec 2002

Abstract excerpt

The gene CEBPA, encoding the transcription factor C/EBPalpha, is crucial for granulocyte differentiation. We investigated the frequency of aberrant CEBPA promotor methylation with the methylation-specific polymerase chain reaction in 70 patients with acute myeloid leukaemia (AML). Two patients, both with M2 morphology, were found to have methylated CEBPA. In one of them, the fusion gene AML1/ETO, reported to...

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PMID: 12472578
DOI: 10.1046/j.1365-2141.2002.03952.x

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