Article
Multivariate analysis and visualization of splicing correlations in single-gene transcriptomes.
BMC bioinformatics - 18 Jan 2007
Emerick Mark C, Parmigiani Giovanni, Agnew William S
Abstract excerpt
BACKGROUND: RNA metabolism, through 'combinatorial splicing', can generate enormous structural diversity in the proteome. Alternative domains may interact, however, with unpredictable phenotypic consequences, necessitating integrated RNA-level regulation of molecular composition. Splicing correlations within transcripts of single genes provide valuable clues to functional relationships among molecular domains as...
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