Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptional changes associated with breast cancer occur as normal human mammary epithelial cells overcome senescence barriers and become immortalized

18 Jan 2007

Abstract excerpt

BACKGROUND: Human mammary epithelial cells (HMEC) overcome two well-characterized genetic and epigenetic barriers as they progress from primary cells to fully immortalized cell lines in vitro. Finite lifespan HMEC overcome an Rb-mediated stress-associated senescence barrier (stasis), and a stringent, telomere-length dependent, barrier (agonescence or crisis, depending on p53 status). HMEC that have overcome the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Genomics and Chromatin Dynamics
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17233903
DOI: 10.1186/1476-4598-6-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptional changes associated with breast cancer occur as normal human mammary epithelial cells overcome senescence barriers and become immortalizedPMID 17233903Read ↗

Stepwise DNA Methylation Changes Are Linked to Escape from Defined Proliferation Barriers and Mammary Epithelial Cell ImmortalizationSemantic proximity Read ↗

Molecular changes accompanying senescence and immortalization of cultured human mammary epithelial cellsSemantic proximity Read ↗

Immortalization of normal human mammary epithelial cells in two steps by direct targeting of senescence barriers does not require gross genomic alterationsSemantic proximity Read ↗

Molecular Distinctions between Stasis and Telomere Attrition Senescence Barriers Shown by Long-term Culture of Normal Human Mammary Epithelial CellsSemantic proximity Read ↗

Age and the means of bypassing stasis influence the intrinsic subtype of immortalized human mammary epithelial cellsSemantic proximity Read ↗

Longitudinal assessment of DNA methylation changes during HPVE6E7-induced immortalization of primary keratinocytesSemantic proximity Read ↗

Coordinated epigenetic remodelling of transcriptional networks occurs during early breast carcinogenesisSemantic proximity Read ↗

Transcriptional Networks and Cellular Senescence in Human Mammary FibroblastsSemantic proximity Read ↗

Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changesSemantic proximity Read ↗

Culture models of human mammary epithelial cell transformation.Semantic proximity Read ↗

Mammary epithelial cell transformation: insights from cell culture and mouse modelsSemantic proximity Read ↗

Proteome profiling of immortalization‐to‐senescence transition of human breast epithelial cells identified MAP2K3 as a senescence‐promoting protein which is downregulated in human breast cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.