Proteome profiling of immortalization‐to‐senescence transition of human breast epithelial cells identified MAP2K3 as a senescence‐promoting protein which is downregulated in human breast cancer

Abstract excerpt

PURPOSE: immortalization is one of the first changes in cells undergoing carcinogenic transformation. Proteome profiling of the immortalization-senescence transition is expected to provide insights into the molecular mechanisms of early tumorigenesis. EXPERIMENTAL DESIGN: 2-DE and MALDI-MS were used to identify proteins in primary human breast epithelial cells, relevant to the immortalization-senescence...

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