Article
Culture models of human mammary epithelial cell transformation.
Journal of mammary gland biology and neoplasia - 1 Oct 2000
Stampfer M R, Yaswen P
Abstract excerpt
Human pre-malignant breast diseases, particularly ductal carcinoma in situ (DCIS) already display several of the aberrant phenotypes found in primary breast cancers, including chromosomal abnormalities, telomerase activity, inactivation of the p53 gene, and overexpression of some oncogenes. Efforts to model early breast carcinogenesis in human cell cultures have largely involved studies of in vitro transformation...
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