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Longitudinal assessment of DNA methylation changes during HPVE6E7-induced immortalization of primary keratinocytes

2 Jan 2015

Abstract excerpt

High-risk human papillomavirus (hrHPV)-induced immortalization and malignant transformation are accompanied by DNA methylation of host genes. To determine when methylation is established during cell immortalization and whether it is hrHPV-type dependent, DNA methylation was studied in a large panel of HPVE6E7-immortalized keratinocyte cell lines. These cell lines displayed different growth behaviors, i.e.,...

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PMID: 25580631
DOI: 10.4161/15592294.2014.990787

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