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Diabetes Insipidus in Mice with a Mutation in Aquaporin-2

18 Aug 2005

Abstract excerpt

Congenital nephrogenic diabetes insipidus (NDI) is a disease characterized by failure of the kidney to concentrate urine in response to vasopressin. Human kindreds with nephrogenic diabetes insipidus have been found to harbor mutations in the vasopressin receptor 2 (Avpr2) gene or the vasopressin-sensitive water channel aquaporin-2 (Aqp2) gene. Development of a treatment is rendered difficult due to the lack of a...

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PMID: 16121255
DOI: 10.1371/journal.pgen.0010020

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