Article
Phase I/II feasibility study evaluating the generation of leukemia-reactive cytotoxic T lymphocyte lines for treatment of patients with relapsed leukemia after allogeneic stem cell transplantation.
Haematologica - 1 Jan 2007
Marijt Erik, Wafelman Amon, van der Hoorn Menno, van Bergen Cornelis, Bongaerts Rian, van Luxemburg-Heijs Simone, van den Muijsenberg Joost, Wolbers Judith Olde, van der Werff Nicole, Willemze Roel, Falkenburg Frederik
Abstract excerpt
BACKGROUND AND OBJECTIVES: Graft-versus-host-disease may be avoided and the likelihood of a graft-versus-leukemia reaction increased by infusion of in vitro generated, leukemia-reactive, cytotoxic T lymphocyte (CTL) lines as treatment for patients with relapsed leukemia after allogeneic stem cell transplantation, instead of donor lymphocyte infusion. The aim of this study phase I/II study was to assess the...
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