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Article

Recent approaches to induction of cytotoxic lymphocytes against leukemia.

Leukemia - 1 Aug 1993

Lotzová E

Abstract excerpt

We have shown that therapy of AML patients in second remission with continuous infusion of IL-2 resulted in generation of cytotoxic lymphocytes in peripheral blood and bone marrow. However, these lymphocytes mediated cytotoxicity only against tumor cell lines, and not against AML blasts. Additional in vitro activation with higher dose of IL-2 was necessary for induction of AML blast oncolysis. This indicates that...

Read the complete abstract on PubMed

Topics

Acute Disease
Humans
Immunotherapy, Adoptive
Interleukin-2
Killer Cells, Lymphokine-Activated
Leukemia, Myeloid
Lymphocyte Activation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Lymphocyte Subsets

Phenotype

T-Lymphocytes, Cytotoxic

Source

Identifiers

PMID: 8361237

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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