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Article

Evolution and divergence of sodium channel genes in vertebrates.

Proceedings of the National Academy of Sciences of the United States of America - 19 Jun 2001

Lopreato G F, Lu Y, Southwell A, Atkinson N S, Hillis D M, Wilcox T P, Zakon H H

Abstract excerpt

Invertebrate species possess one or two Na+ channel genes, yet there are 10 in mammals. When did this explosive growth come about during vertebrate evolution? All mammalian Na+ channel genes reside on four chromosomes. It has been suggested that this came about by multiple duplications of an ancestral chromosome with a single Na+ channel gene followed by tandem duplications of Na+ channel genes on some of these...

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PMID: 11416226
DOI: 10.1073/pnas.131171798
PMCID: PMC34712

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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