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Article

Leucine-rich repeat kinase 1: a paralog of LRRK2 and a candidate gene for Parkinson's disease.

Neurogenetics - 1 Apr 2007

Taylor Julie P, Hulihan Mary M, Kachergus Jennifer M, Melrose Heather L, Lincoln Sarah J, Hinkle Kelly M, Stone Jeremy T, Ross Owen A, Hauser Robert, Aasly Jan, Gasser Thomas, Payami Haydeh, Wszolek Zbigniew K, Farrer Matthew J

Abstract excerpt

Leucine-rich repeat kinase 1 gene (LRRK1) on chromosome 15q26.3 is a paralog of LRRK2 in which multiple substitutions were recently linked to Parkinson's disease. We have examined the exon-intron structure of the gene and the expressed mRNA sequence in brain. LRRK1 sequencing analysis in 95 proba...

Topics

Alternative Splicing
Amino Acid Sequence
Amino Acid Substitution
Base Pairing
Base Sequence
Exons
Female
Humans
Introns
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Parkinson Disease

Pedigree

Phylogeny

Protein Serine-Threonine Kinases

Source

Identifiers

PMID: 17225181
DOI: 10.1007/s10048-006-0075-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-17225181-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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