Article
Genome-wide linkage mapping for valve calcification susceptibility loci in hypertensive sibships: the Hypertension Genetic Epidemiology Network Study.
Hypertension (Dallas, Tex. : 1979) - 1 Mar 2007
Bella Jonathan N, Tang Weihong, Kraja Aldi, Rao Dabeeru C, Hunt Steven C, Miller Michael B, Palmieri Vittorio, Roman Mary J, Kitzman Dalane W, Oberman Albert, Devereux Richard B, Arnett Donna K
Abstract excerpt
It remains unclear whether genetic factors contribute to the susceptibility to valve calcification. Accordingly, echocardiograms and genotyping were performed in 1871 hypertensive siblings who participated in the Hypertension Genetic Epidemiology Network Study. Genome-wide affected sibpair nonparametric linkage analysis was conducted using the allele-sharing method implemented in the Merlin computer program. A...
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