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Article

P60-c-src suppresses apoptosis through inhibition of caspase 8 activation in hepatoma cells, but not in primary hepatocytes.

Journal of hepatology - 1 Apr 2007

De Toni Enrico N, Kuntzen Christian, Gerbes Alexander L, Thasler Wolfgang E, Sonuc Nilüfer, Mucha Simon R, Camaj Peter, Bruns Christiane, Göke Burkhard, Eichhorst Sören T

Abstract excerpt

BACKGROUND/AIMS: Failure to induce apoptosis triggered by members of the death receptor family has been described in hepatocellular carcinoma (HCC) and sensitization of malignant cells to pro-apoptotic molecules such as TRAIL has been proposed as an alternative cancer therapy. Limiting to this approach are the resistance of many tumor cells to TRAIL and safety concerns about the toxicity of TRAIL in normal...

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Identifiers

PMID: 17224200
DOI: 10.1016/j.jhep.2006.10.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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