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Article

The quantitative trait gene latexin influences the size of the hematopoietic stem cell population in mice.

Nature genetics - 1 Feb 2007

Liang Ying, Jansen Michael, Aronow Bruce, Geiger Hartmut, Van Zant Gary

Abstract excerpt

We mapped quantitative trait loci that accounted for the variation in hematopoietic stem cell (HSC) numbers between young adult C57BL/6 (B6) and DBA/2 (D2) mice. In reciprocal chromosome 3 congenic mice, introgressed D2 alleles increased HSC numbers owing to enhanced proliferation and self-renewal and reduced apoptosis, whereas B6 alleles had the opposite effects. Using oligonucleotide arrays, real-time PCR and...

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Source

Identifiers

PMID: 17220891
DOI: 10.1038/ng1938

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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