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Article

Genetic control of hematopoietic stem cell frequency in mice is mostly cell autonomous.

Blood - 1 Apr 2000

Müller-Sieburg C E, Cho R H, Sieburg H B, Kupriyanov S, Riblet R

Abstract excerpt

Previously we reported that the size of the stem cell compartment (measured as LTC-IC) is 11-fold greater in DBA/2 than in C57BL/6 mice, and we identified genes that regulate the size of the stem cell pool. To determine whether stem cell intrinsic or extrinsic events account for these differences, we created chimeras by aggregating morulae from the strains C57BL/6 and DBA/2. In these chimeras stem cells of both...

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PMID: 10733521

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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