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Article

A loss of function screen of identified genome-wide association study Loci reveals new genes controlling hematopoiesis.

PLoS genetics - 1 Jul 2014

Bielczyk-Maczyńska Ewa, Serbanovic-Canic Jovana, Ferreira Lauren, Soranzo Nicole, Stemple Derek L, Ouwehand Willem H, Cvejic Ana

Abstract excerpt

The formation of mature cells by blood stem cells is very well understood at the cellular level and we know many of the key transcription factors that control fate decisions. However, many upstream signalling and downstream effector processes are only partially understood. Genome wide association studies (GWAS) have been particularly useful in providing new directions to dissect these pathways. A GWAS...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25010335
DOI: 10.1371/journal.pgen.1004450
PMCID: PMC4091788

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