Article
Genetic control of the frequency of hematopoietic stem cells in mice: mapping of a candidate locus to chromosome 1.
The Journal of experimental medicine - 1 Mar 1996
Müller-Sieburg C E, Riblet R
Abstract excerpt
The genetic elements that govern the differentiation and proliferation of hematopoietic stem cells remain to be defined. We describe here marked strain-specific differences in the frequency of long-term culture-initiating cells (LTC-IC) in the bone marrow of different strains of mice. Mice of C57...
Topics
- Animals
- Bone Marrow Cells
- Cell Differentiation
- Cell Division
- Cell Line
- Cells, Cultured
- Chromosome Mapping
- Colony-Forming Units Assay
- Genotype
- Granulocytes
- Hematopoietic Stem Cells
- Kinetics
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Polymerase Chain Reaction