Article
A case-control investigation of immune function gene polymorphisms and risk of testicular germ cell tumors.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2007
Purdue Mark P, Sakoda Lori C, Graubard Barry I, Welch Robert, Chanock Stephen J, Sesterhenn Isabel A, Rubertone Mark V, Erickson R Loren, McGlynn Katherine A
Abstract excerpt
There is reason to suspect that testicular germ cell tumor (TGCT) development may be influenced by cytokines, secreted proteins that modulate tumor immune surveillance activity as well as a variety of processes in the testis. To address this hypothesis, we conducted a case-control analysis (508 cases, 608 controls) of 32 putatively functional single-nucleotide polymorphisms (SNP) in 16 immune function genes among...
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