Article
Phenotypic and population differences in the association between CILP and lumbar disc disease.
Journal of medical genetics - 1 Apr 2007
Virtanen I M, Song Y Q, Cheung K M C, Ala-Kokko L, Karppinen J, Ho D W H, Luk K D K, Yip S P, Leong J C Y, Cheah K S E, Sham P, Chan D
Abstract excerpt
BACKGROUND: Lumbar disc disease (LDD) is one of the leading causes of disability in the working-age population. A functional single-nucleotide polymorphism (SNP), +1184T-->C, in exon 8 of the cartilage intermediate layer protein gene (CILP) was recently identified as a risk factor for LDD in the Japanese population (odds ratio (OR) 1.61, 95% CI 1.31 to 1.98), with implications for impaired transforming growth...
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